RAPID LOSS ON DRYING
Rapid loss on drying instrumentation has proven to provide a more desirable method of moisture measurement when compared to traditional loss on drying
techniques. It addresses the drawbacks associated with conventional loss on drying while maintaining the ease of use application. The reduction in test
times increases manufacturing efficiency while simultaneously reducing energy costs. Additionally, this instrumentation is able to provide real time
moisture measurements to help users optimize moisture measurement methods.
Relative Humidity Sensor Technology
Relative Humidity (RH) was first used as a method of moisture determination in 1997 with the introduction of the Computrac® 3000 Moisture
Analyzer by Arizona Instrument LLC.
This method uses a thermoset polymer capacitor that has a selective response when in the presence of water, the same way that many RH sensors work in
traditional settings such as houses, laboratory controlled environments, and dry boxes. A material is sealed in a sample vial, and then transported into an
oven with inert gas blown through it. As the material gets hot, water molecules evolve off and are carried to the sensor via the carrier gas. The sensor is
exposed to the water molecules and a measurable change in the electronic activity takes place. In addition, no solvent and no material processing for
lyophilized pharmaceuticals are necessary for analysis.
Since 1997 Arizona Instrument LLC has further developed this method of analysis and designed an instrument designed to meet the needs of the pharmaceutical
industry. The Computrac® Vapor Pro® Rx is capable of testing a variety of samples using different size vials with a current
sensitivity able to accurately and reliably detect moisture as low as 100ppm.
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Instruments adhere to 21 CFR Part 11
IQ/OQ/PQ Validation Packages Available
Calibrations use NIST Traceable Standards
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Relative Humidity (RH) Sensor Technology
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Instrumentation
COMPUTRAC® VAPOR PRO® RX
Moisture Specific Analyzer, Relative Humidity Sensor Technology
Application Data |
Brochure |
Manual
COMPUTRAC® MAX® 4000XL
Moisture | Solids Analyzer, Loss On Drying Technology
Application Data |
Brochure |
Parts |
Manual